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By inhibiting the action of DPP-4, sitagliptin helps to increase the levels of these helpful hormones, which in turn stimulates insulin production and lowers blood glucose levels

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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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