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But in reality: They were obese a year ago (BMI 32) Lost around 14kg using GLP-1s from a D2C provider (no detail on their electronic health record) Still have underlying metabolic syndrome If we assume about 65% of people who start GLP-1 medications quit by the end of year one, that creates a big problem

Individual tolerance to GLP-1s varies but the most common side effects are nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and runny nose or sore throat

The medications and therapeutic strategies discussed may not be suitable for everyone and can have significant risks and side effects

While this potential blockbuster treatment presents considerable opportunities for pharma partners, there are, of course, challenges, specifically in terms of satisfying demand

Less commonly recognized but still valid qualifying conditions include prediabetes (elevated fasting glucose or A1C between 5.7-6.4%), polycystic ovary syndrome, non-alcoholic fatty liver disease, osteoarthritis of weight-bearing joints, and chronic kidney disease