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Orforglipron Versus Semaglutide Researchers enrolled nearly 1,700 adults with Type 2 diabetes inadequately controlled with metformin and HbA1c levels between 53 and 91 mmol/mol

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The dual GLP-1/GIP mechanism proved more potent than single-pathway GLP-1 therapies alone, making tirzepatide a preferred choice for patients seeking maximum appetite suppression and metabolic benefit

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The STEP and SURPASS clinical trial programs for tirzepatide documented patient-reported improvements in emotional well-being and quality-of-life metrics, including reduced emotional eating patterns tied to depression