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Risk factors that may influence the decision to pause treatment include: Being in the dose-escalation phase of GLP-1 therapy Experiencing active gastrointestinal symptoms (nausea, vomiting, bloating) Having known gastroparesis or other conditions affecting gastric emptying Taking concurrent medications that further delay gastric emptying (e.g., opioids) Undergoing procedures with higher aspiration risk (e.g., emergency surgery, airway surgery) If your anaesthetist or surgical team advises temporary cessation based on your individual risk assessment, the timing will depend on the specific medication: Daily injections (such as liraglutide): Typically paused 24 hours before surgery Weekly injections (such as semaglutide, dulaglutide): Often paused with the last dose given at least 7 days before surgery Oral semaglutide (Rybelsus): Usually paused 24 hours before surgery However, these timings may vary according to local NHS Trust protocols and individual clinical assessment

The side effect profile is similar in type, with nausea, constipation, and diarrhea being most common, but the severity and tolerability may differ due to the different receptor activation pattern

Microdosing GLP-1 means using a fraction of the standard therapeutic dose, typically 0.05 to 0.25mg of semaglutide weekly versus the standard 0.25 to 2.4mg, with the goal of reducing side effects while maintaining appetite control

Total gross commercial spending on GLP-1 drugs in Massachusetts is expected to exceed $270 million in 2023, more than double the $125 million in spending in 2022, according to presentation slides shared at a commission meeting last week

Li Y, Chigurupati S, Holloway H, et al

Before starting treatment, our experienced healthcare professionals at Neuvo Medical Spa will conduct a comprehensive evaluation to ensure Semaglutide GLP-1 is appropriate for you