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however, new formulations or delivery methods, such as intrathecal or transdermal delivery systems, could vastly enhance the delivery of GLP-1RAs to sites of action in targeting the CNS and spinal cord

Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T: Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice

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Furthermore, GLP-1R agonism has been found to reduce alcohol intake in mice (Egecioglu et al., 2013b