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Secondly, GLP-1 receptor agonists carry important safety considerations including risk of pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (based on rodent studies, though human relevance remains uncertain)

These medications function by reproducing the GLP-1 hormone effects which control blood sugar levels along with appetite regulation

RAMP2 expression is shown to negatively modulate maximal inhibitory G i recruitment to the GcgR (40%), enhance maximal glucagon-stimulated cAMP production (2-fold) and potency (10-fold), improve oxyntomodulin-induced maximal cAMP production by 133%, and mediate GcgR binding promiscuity towards GLP-1R agonists when RAMP2 is not expressed [187]

Source [14] GLP-1 medications and excisional surgery The rise in the use of GLP-1 medications for weight loss has led to more people seeking out excisional surgeries to remove loose skin following significant weight loss

Seth Kipnis, medical director of bariatric and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center, noted that there have been "rare and unusual side effects" from this class of medications, but he believes the vision changes seem to be more related to the rapid blood sugar changes caused by the medications than to the medications themselves