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A low-fibre diet has historically been associated with increased risk, as it may lead to harder stools and increased pressure within the colon during bowel movements

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Appetite suppression was observed at doses 0.3 mg while significant reductions in circulating triglycerides, branched-chained amino-acids and fasting and postprandial glucagon levels were also seen, along with increasing insulin secretion

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No other issues were flagged, according to Alvotech