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The most common concerns involve gallbladder events, pancreatitis risk, and potential thyroid effects, all of which occur at low rates but warrant monitoring through regular medical check-ups

Appropriate candidates typically include: Adults with BMI 30 kg/m , or Adults with BMI 27 kg/m who present with at least one weight-related comorbidity (e.g., hypertension, dyslipidemia, or type 2 diabetes)

Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy

Furthermore, it supports investigations into glucose-dependent insulin secretion pathways

By stimulating both GIP and GLP-1 pathways, it promotes insulin secretion, suppresses glucagon release, and delays gastric emptying

Use reliable contraception until glycaemic targets are met and all medications are optimised for pregnancy