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Any PBM reforms should seek to remove distortions from the marketand, in particular, distortions created by government policies.

April 9, 2024 One of the first studies to attempt to treat early-stageheart failurein patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not takingSGLT2inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart

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The tradeoff: retatrutide appeared to show higher rates of nausea (42.4%), diarrhea (32.0%), and vomiting (25.3%) than tirzepatide or orforglipron at their top doses