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Phase III trials (TRIUMPH 1-4) are ongoing to confirm efficacy and safety in broader populations

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Similarly, the subcutaneously once weekly formulation of the GLP-1 receptor agonist semaglutide showed equally promising results for weight maintenance [132]

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In a clinical trial conducted by Wilding et al [96] in adults with overweight or obesity, semaglutide 2.4 mg injections once weekly led to significant reductions in both fat mass (8.36 kg vs 1.37 kg placebo-treated controls) and lean mass (5.26 kg vs 1.83 kg in the control group)