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Researchers identified 35 NAION cases among more than 159,000 users compared to 19 cases in those not taking the drugs

However, GLP-1 has a very short half-life of about 1.5 minutes and is rapidly suppressed by an enzyme called dipeptidyl peptidase-4 (DPP-4)

DKD is considered to occur as a result of an interplay between metabolic and hemodynamic factors (58), with many of the putative pathways leading to injury having already been delineated (59)

Boye KS, Poon JL, Lando LF, Sapin H, Huh R, Wang M, Williamson S, Patel H (2024) Tirzepatide improved health-related quality of life compared with insulin lispro in basal insulin-treated adults with type 2 diabetes and inadequate glycaemic control: a randomised controlled phase 3b trial (SURPASS-6)