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Addition of LINA to EMPA enhances USE via reduction of ENaC expression, reduces UAE, and inhibits kidney injury in deoxycorticosterone acetate/salt (DS)-administered, uninephrectomized mice DS-administered, uninephrectomized mice (DS mice) have been known to exhibit glomerular hyperfiltration and severe kidney injury with ENaC activation 24

doi:10.1172/jci170771
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Am J Roentgenol Radium Ther Nucl Med