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A GLP-1/GIP/Glucagon receptor agonist, Retatrutide and an experimental ERR agonist SLU-PP-332 coupled with mitochondrial activity and endurance performance is one of such combinations.

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Switching to the oral small molecule glucagon-like peptide-1 (GLP-1) orforglipron after taking injectable GLP-1s helped patients maintain mostbut not allof their weight loss, according to a clinical trial led by Weill Cornell Medicine and NewYork-Presbyterian investigators.