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Such improvements are crucial in mitigating the risk of obesity-related comorbidities, notably cardiovascular diseases and type 2 diabetes, which stand as leading contributors to global morbidity and mortality

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We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity