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Even in healthy women, increased insulin resistance has been reported during the luteal phase of the menstrual cycle in healthy women (62)

There is also uncertainty whether or not weight loss will remain even with continued usage of the medication after five years

Weight loss varies widely based on starting weight, adherence, lifestyle factors, and dose

N Engl J Med (2017) 377:64457

A separate nausea-friendly dose-day template is included

For many, the thought of scheduling in-person appointments, dealing with insurance hurdles, and making trips to the pharmacy is a significant barrier to starting their weight loss journey