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Because the most translatable animal models are humanized constructs rather than the exhaustively validated wild-type rodents behind the peptide literature, evidence synthesis should lean comparatively more on the human trials and be cautious about importing conclusions from peptide rodent studies

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This new indication, based on the SOUL data, marks even further advancement and showcases the versatility of semaglutide while expanding options for millions of people. As the only FDA-approved GLP-1 therapy in a pill, now recognized for its proven cardiovascular benefits, a new benchmark has been set for future oral innovations, added Dave Moore, executive vice president of US Operations for Novo Nordisk