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2022;1(6) doi: 10.1056/evidoa2200014

Vipul Patil 6

Liraglutide is the oldest of the three and has the most evidence for antipsychotic-induced weight gain, with positive results from two small RCTs in schizophrenic disorders at a dose of 1.83.0 mg/day (Lee K et al, Gen Hosp Psych 2022;78:5867)

5 The bioactive forms, GLP-1(737) and most abundantly, GLP-1(736)NH 2 , are inactivated by dipeptidyl peptidase-4 (DPP-4)

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In summary, GLP-1RA could reduce the proliferation of effector T cells, promote the generation of Treg cells, and enhance the immunosuppressive function of Treg cells ( Figure 3 ) (91)