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Healthcare providers may avoid prescribing topiramate for individuals with: A history of suicidal thoughts or behaviors A history of kidney stones Metabolic acidosis Bone conditions like osteopenia, osteomalacia, or osteoporosis Glaucoma Respiratory issues like asthma or COPD Depression or mood disorders Growth problems Thyroid disease Liver disease Kidney diseases Topiramate can increase the risk of kidney stones, so it's essential to stay well-hydrated while taking the medication

Experts highlight that outdated medications often fail to deliver the expected therapeutic effects, which can jeopardize your treatment outcomes

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Given their dual benefits in obesity and inflammation regulation, GLP-1RAs medications hold potential as disease-modifying therapies for OA