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Los niveles plasmticos de GLP-1 son bajos en el estado de ayuno, en el rango de 5-10 pmol/l aumentando rpidamente luego de la ingesta a 15-50 pmol/l

And the first GLP-1 for weight loss was approved in 2014, which suddenly seems like a long time ago

Additionally, oral semaglutide 14 mg showed a significant reduction in body weight compared to liraglutide 1.8 mg in the PIONEER 4 trial [28]

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GLP-1-based therapies offer a pharmacological intervention that targets these mechanisms directly, allowing for more effective management of obesity

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