semaglutide anti inflammatory effects Spotlight on the Mechanism of Action of Semaglutide Side Effects: What Patients

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Wegovy Frequently Asked Questions ABOUT WEGOVY The Wegovy pen and the Wegovy pill are indicated in combination with a reduced-calorie diet and increased physical activity 1 : To reduce the risk of MACE (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and either obesity or overweight To reduce excess body weight and maintain weight reduction long term in: - Adults with obesity - Adults with overweight in the presence of at least one weight-related comorbid condition The Wegovy pen is indicated in combination with a reduced-calorie diet and increased physical activity 1 : To reduce excess body weight and maintain weight reduction long term in: - Pediatric patients aged 12 years and older with obesity MACE, major adverse cardiovascular events

All GLP-1 medications start low and gradually increase every 4 weeks (weekly formulations) or weekly (daily formulations) to minimize gastrointestinal side effects

Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, et al

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Key considerations remain: Adverse Effects: Gastrointestinal Effects o Nausea, vomiting, abdominal pain, bloating most common and dose-related o Constipation or diarrhea due to slowed intestinal motility o Delayed gastric emptying may worsen symptoms of gastroparesis and complicate oral medication absorption Hepatobiliary & Pancreatic Risks o Gallstones (cholelithiasis) linked to rapid weight loss and altered biliary motility o Pancreatitis rare but potentially severe