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A study of retatrutide (LY3437943) compared with tirzepatide in participants who have obesity or overweight (TRIUMPH-5) (NCT06662383)

doi: 10.3390/microorganisms10102061

The body often requires time to adjust to GLP-1 therapy, and energy levels typically improve as side effects diminish and the body adapts to metabolic changes

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Further supporting this mechanism, peripheral GLP-1 infusion improves glucose tolerance in intact animals, but this benefit is lost following the ablation of vagal signaling (Imeryuz et al., 1997