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n = 26) and high fat diet (HFD- 60 kJ% fat, 20 kJ% protein, 20 kJ% carbohydrates D12492 SsniffGermany

Phase 2 data of retatrutide, a similar triple agonist developed by Eli Lilly, has shown a remarkable 24% weight loss after 48 wk of treatment, without reaching a plateau (1)

The point here is simply that estrogen status appears woven into how the female body responds to incretin peptides, which helps explain the consistent percentage edge women show in the data

With sufficient decline in -cell mass (loss of approximately 7080%), most people will progress to overt diabetes (stage 3), which can be managed initially with non-insulin therapies (stage 3a)