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[2] [7] These findings led regulatory authorities, including the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), to include specific warnings and precautions in the prescribing information for all GLP-1 medications

Losing fat while preserving lean mass is very different from simply losing weight

Efforts to encourage persistent use of GLP-1 RA, as successful in clinical trials, may be necessary to achieve better persistence in clinical practice as well

Drucker Peripherally administered GLP-1R agonists reduce food intake and body weight through signaling mechanisms requiring functional GLP-1Rs in the ARC of the hypothalamus

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Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, et al