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While pancreatic -cells are the principal therapeutic target, GLP-1Rs are widely expressed in -cells, exocrine pancreas, intestinal mucosa, renal tubules, pulmonary epithelium, selected brain nuclei, and the cardiac sinoatrial node

These therapies may exert prophylactic effects, particularly in individuals with DM2, who are already at elevated risk for AD 17

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PlexusDx also offers GLP-Squared (a compounded dual-agent injection starting at $249/mo) and oral formulations for patients seeking alternatives to injections