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PubMed Central , Journal of the ASEAN Federation of Endocrine Societies , vol
ODT formulations have not undergone clinical trials and their effectiveness has not been established.
However, berberine is not approved as a pharmaceutical drug in most countries and lacks the decades of safety and efficacy data that metformin carries
In the 70s, other appetite suppressants appeared on the scene, recommended for safe (but limited) usage
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