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71 Allergy and angioedema Due to the nature of their route of administration, as subcutaneously injected peptides, and the different immunogenic properties between the class members, hypersensitivity, and immunological reactions were anticipated with the concomitant use

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Approved indications for GLP-1s: Cardiovascular disease Chronic kidney disease Obesity Sleep apnea Type 2 diabetes Metabolic dysfunction-associated steatohepatitis (MASH) Potential future indications: (indications with asterisks have already been investigated in randomized clinical trials) Substance use disorders (alcohol, tobacco) Alzheimers Parkinsons Cancer prevention Diabetes prevention* Diabetic retinopathy Heart failure* Osteoarthritis* Peripheral artery disease* Polycystic ovarian syndrome Psoriasis When I was at the ADAs 85th Scientific Sessions this year, what was quite apparent was just how quickly the field has progressed beyond GLP-1s