survodutide vs tirzepatide What is the pipeline for future medications for obesity? Incretins: How we got here,

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A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating

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3c, constricted by 5.4 1.0% at n = 25 pericytes in 7 hearts, compared to 23.0 2.6% in continuous OGD without Ex4 at n = 21 pericytes in 6 hearts

The FDA-approved titration schedule begins at 2.5 mg weekly for four weeks, then increases to 5 mg weekly

One side effect that gets people asking questions: dysesthesia TRIUMPH4 reporting mentions dysesthesia (odd, uncomfortable sensations like tingling/burning) and says it was generally mild and infrequently led to discontinuation