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However, it is critical to distinguish between biological activity and therapeutic efficacy: these biomarker changes did not translate into any measurable clinical benefit, and should therefore be interpreted as evidence of limited central engagement rather than as support for the prevention-dominant hypothesis

Zhang Y, Parajuli KR, Fava GE et al (2019) GLP-1 receptor in pancreatic alpha-cells regulates glucagon secretion in a glucose-dependent bidirectional manner
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Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk was published in Nature Cardiovascular Research in April 2024

Liu, Mark A

Without this information, the brand's claims about transdermal effectiveness cannot be independently verified
