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Goldstein T, Kark JD, Berry EM, Adler B, Ziv E, Raz I

Tirzepatide, a dual GIP/GLP-1 agonist, showed up to 20.9% average weight loss in SURMOUNT-1 at 72 weeks

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Increased activity of this pathway is related to enhanced aging and the occurrence of diseases like T2D and CVDs, whereas decreased IGF-1 signaling increases the lifespans of model organisms like worms, flies, and mice
