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And eventually, it may be evidence payers, clinicians, employers, and patients all start asking for.

Glucagon-like peptide-1 (GLP-1) receptor agonists were touted as breakthrough drugsin 2023 and their popularity has soared since. More than 4 million items of tirzepatide and semaglutide were dispensed on the NHS in England in 2025/20261, while around2.5 million people each monthaccessed GLP-1s privately at the end of 2025, according to James Kingsland, chair of []

But without scientific data, the risks may outweigh the benefits.

Fatty liver: Can lead to fatty liver disease, which may progress to liver dysfunction, cirrhosis, or require liver transplant

Eli Lillys first nine months of 2025 underscored the scale of the GLP-1 surge: Mounjaro and Zepbound generated $39.5 billion in revenue and surpasses Mercks Keytruda as the worlds best-selling medicine[5]