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Flier, for being an important part of the early discovery work, almost four decades ago.

Rationale Obesity remains a major global health challenge, severely affecting metabolic and cardiovascular health

A major pathological feature of b...

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By 2030, the global prevalence of obesity is expected to reach one billion

Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases