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Greater reductions in body weight were associated with greater reductions in the prevalence of patients meeting the criteria for metabolic syndrome and its individual components

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The net effect is that after MBS, endogenous GLP-1 primarily acts on the brain to inhibit appetite, while only 10% of the secreted GLP-1 reaches the pancreas

However, surgery carries well-documented risks, such as gastric strictures, anastomotic leaks, thromboembolic events, infections, and the need for reoperations

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