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Keeping your energy up by not doing extended fasts

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Clinical trials show ~15% body weight reduction with semaglutide and up to 21% with tirzepatide

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This is because of the connection between weight and the hypothalamic-pituitary-ovarian axis, according to a 2020 article in The Journal of Clinical Endocrinology and Metabolism

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Interestingly, a recent study has shown that 14 days of cocaine self-administration in rats was associated with increased ghrelin and GLP-1 plasma levels while leptin and insulin levels were decreased [143]

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