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Although the overall risk is low, it is a significant concern

Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Kreymann B., Williams G., Ghatei M.A., Bloom S.R

If you observe any changes in skin color, irritation, or discomfort, change the injection site

What to Expect If You Start the Combination If your provider agrees that taking Wegovy and naltrexone together is the right move, they will likely start you on a very low dose of the second medication

This is the same approach you would use when traveling with semaglutide , just applied to a home emergency situation