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In SURPASS-2, severe hypoglycemia (requiring third-party assistance) occurred in fewer than 0.6% of tirzepatide-treated participants not on sulfonylureas or insulin, mechanistically expected given the glucose-dependent clamp

doi: 10.1161/CIRCULATIONAHA.124.067676

BCBS is not a single insurance company

Diabetes: from research to clinical practice: Volume 4 [Internet]

It suggests that the dose-response curve for tirzepatide is steep at the lower end

Liraglutide users without diabetes showed higher chances of delayed gastric emptying (139%) and ileus (32%) compared to other weight loss medications
