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As mentioned above, alterations in IEC subpopulations have been described previously in the context of intestinal inflammation, in particular for mucin-producing goblet cell and antimicrobial-peptide-producing Paneth cells

It is important to note that fibre requirements may change throughout the course of GLP-1 treatment

Phase 3 retatrutide trials suggest higher weight loss with the 12 mg dose (28.7% in TRIUMPH-4) than with Mounjaro at its 15 mg dose (around 22.5% in SURMOUNT-1)

Alessi DR, Pearce LR, Garcia-Martinez JM