gip and glp-1 receptor agonist Major physiological roles of GIP. Tirzepatide is acting as an Possible mechanisms of the interaction

Not to get too deep into the science, but a PPAR agonist delivered selectively because of GLP1 and GIP receptors may mean that we can see the insulin sensitizing benefit of this drug class without the negative side effects that prior meds in this class have suffered from

The STEP trials are testing semaglutide at the higher dose of 2.4 mg/week (as compared to 1.0 mg/week for the original diabetes indication), specifically for promoting weight loss, regardless of the presence of type 2 diabetes

We will examine liver health improvements and brain protection, exploring how these medications work beyond weight loss to enhance overall wellness

DCA, deoxycholic acid

Guidelines for cardiovascular risk reduction in patients with type 2 diabetes: JACC guideline comparison

Preclinical studies conducted in C57/Bl6 diet-induced obese (DIO) mice demonstrated that LY3437943 is effective in reducing body weight and calorie intake