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GIP Agonism Effect in Diabetic Nephropathy The nephroprotective effect of tirzepatide has not been directly studied, however, the effect of GIP agonism on inflammation has been extensively documented (Figure 2)

2012) Exenatide has 53% homology with GLP-1

Hirata Y, Kurobe H, Nishio C, Tanaka K, Fukuda D, Uematsu E, Nishimoto S, Soeki T, Harada N, Sakaue H

In vivo doseresponse on food intake/body weight in diet-induced obese (DIO) rats In our first preclinical experiment, we performed a dose escalation study in DIO rats to compare responses to treatment with GEP44 and Ex-4

10 In particular, semaglutide was most successful at reducing alanine transaminase (mean difference, 14.70 U/L), aspartate transaminase (mean difference, 9.32 U/L), g-glutamyl transferase (mean difference, 16.56 U/L), and liver stif fness measurement (mean difference, 3.08 kPa) compared with the other medications studied, whereas liraglutide demonstrated efficacy in reducing subcutaneous adipose tissue (mean difference, 30.27 cm 2 ) and liver fat fraction (mean difference, 5.16%)

Understanding your lab landscape before, during, and after GLP-1 therapy initiation is essential for safe, personalized care