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The key distinction is between occasional timing shifts and chronic inconsistency

Missing doses of Ozempic (semaglutide) may cause nausea, extreme hunger, and constipation
In the EU, the procedure is less centralized and despite the fact that only a single application is submitted via a common electronic platform (Clinical Trial Information System, CTIS), national authorities in each of the member countries must issue separate permissions

Again, this is secondary to the glucose-dependent mechanism of incretin-based therapies wherein increased insulinotropic activity occurs only in the presence of hyperglycemia
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Maykish A, Sikalidis AK
