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5 They are associated with numerous chronic diseases and represent significant contributors to both morbidity and mortality

In addition, SGLT-2 inhibitors have shown benefit in patients with both HFrEF and HFpEF independently of diabetes status, which opens exciting possibilities for the use of these therapies in patients at risk for or with established CV or kidney disease without T2D

Comparatively, with the fluctuating plasma levels of exenatide observed with twice-daily injections, deceleration of gastric emptying is fully maintained

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Given the high prevalence of fatty liver in diabetic patients (estimated at 5570%), initiating or switching to a GLP-1 agonist addresses both conditions simultaneously

Pharmacokinetics and clinical use of incretin-based therapies in patients with chronic kidney disease and type 2 diabetes