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A 2024 study in Obesity found that patients on a reduced quarterly semaglutide dose maintained 65% more weight loss than those who stopped entirely

Stamford, CT 06905 Sources Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes New England Journal of Medicine GLP-1 Receptor Agonists and Cardiovascular Risk Reduction The Lancet Mechanisms of GLP-1 in Glucose Regulation Nature Reviews Endocrinology Semaglutide Treatment Effect in People with Obesity (STEP Trials) New England Journal of Medicine Inflammation and Insulin Resistance Cell Metabolism

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HCA Healthcare, one of the largest US health systems, told employees it wouldnt keep covering weight loss drugs Zepbound and Wegovy this year , citing a 90% increase in 2025 costs from GLP-1 obesity medications, per STAT

The Phase 2 data shows averages, and averages hide enormous individual variation

Some people may feel dizzy, light-headed, shaky, or sweaty, which could be due to the medication, dehydration, low blood sugar or other complications