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Neuroinflammation is a critical factor contributing to cognitive dysfunction and neurodegenerative diseases
In the cellular studies, NNC0090-2746 and tirzepatide showed comparable efficacy and potency at multiple signaling pathways connected to the GIPR
[DOI] [PubMed] [Google Scholar] 408.Tan Y.V., Couvineau A., Murail S., Ceraudo E., Neumann J.M., Lacapere J.J

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While such a proximal-distal loop might indeed exist, it cannot be ruled out that while fewer in number, L-cells in the upper intestine are sufficient for the rapid induction of GLP-1 secretion following nutrient intake [[316], [317], [318]]
