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GLP-1 drugs target the Area Postrema and dorsal vagal complex , brain regions that control vomiting and food aversion

doi: 10.1113/jphysiol.1970.sp009155 [DOI] [PMC free article] [PubMed] [Google Scholar] 11

[39] recruited healthy male subjects and found that HR was elevated by 8.2 in the exenatide group compared with the placebo group

10.1016/j.diabres.2011.01.016 [DOI] [PubMed] [Google Scholar] 138.Akarte AS, Srinivasan BP, Gandhi S

These combined effects may explain why retatrutide has produced significant weight loss in clinical trials

It does three important things: It signals your pancreas to release insulin in proportion to how much glucose is arriving from food- preventing blood sugar from spiking too high after meals
