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Last Updated on 2024 7 27 by GLP-1 GLP-1 GLP-1 GLP-1 RybelsusSemaglutide GLP-1 Table of Contents 20 80 Incretin 60% -1GLP-1GIP 2 2 GLP-1 GLP-1 GLP-1 GLP-1 2 GLP-1 GLP-1 DPP-4 GLP-1 VictozaTrulicity Ozempic GLP-1 8 Saxenda Wegovy Wegovy 112/2 Ozepmic Ozempic off-label use GLP-1 Novo Nordisk RybelsusSemaglutide Ozempic Rybelsus Eligen (Emisphere, NJ, USA) Salcaprozate sodium, SNAC Semaglutide SNAC semaglutide pH SNAC semaglutide Semaglutide Semaglutide PIONEER 1 10 HbA1c 1.0-1.8% 2~5 PIONEER 1: QD oral sema vs placebo in people with T2DM treated with diet and exercise only 3, 7, 14 mg HbA1C 7 14 mg PIONEER 2: QD oral sema vs empagliflozin 25 mg in people with T2DM 14 mg HbA1C empagliflozin 25 mg PIONEER 3: QD oral sema vs sitagliptin 100 mg in people with T2DM 7 14 mg HbA1C 3, 7, 14 mg PIONEER 4: QD oral sema vs Victoza 1.8 mg and placebo in people with T2DM 14 mg HbA1C Victoza PIONEER 5: QD oral sema vs placebo in people with T2DM and moderate renal impairment 14 mg HbA1C PIONEER 7: QD oral sema using a flexible dose adjustment based on clinical evaluation vs sitagliptin 100 mg in people with T2DM 14 mg HbA1C sitagliptin PIONEER 8: Effects of QD oral sema vs placebo in people with long duration of T2DM treated with insulin 3, 7, 14 mg HbA1C PIONEER 6 CV safety studyPIONEER 9 PIONEER 10 Japanese studies GLP-1 SaxendaLiraglutide semaglutideNovo Nordisk Lorcaserin Orlistat Saxenda 4 5 2487 Saxenda 9.2% 1/3 10% 3.2 4.5/3 x 4 4+2R 5 NOVO NORDISK#NVO

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No water is needed

Once-weekly formulations such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity) can be given at any time of day, whilst twice-daily exenatide requires administration before meals