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Although the quality of the evidence was low, limited by small numbers and a short duration of therapy (mostly less than 12 weeks), the improvement in disease activity and quality of life scores is compelling

2007;293:E6049

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., Neyrinck A.M., Fava F., Tuohy K.M., Chabo C., et al

Why real-world results sometimes lag behind trial data Trial participants receive regular monitoring, dietary counseling, and structured follow-up that promotes adherence and optimal behavior

This is when most patients start seeing consistent, steady changes on the scale and in how their clothes fit
