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When used under medical supervision, semaglutide GLP-1 can help reduce hunger, increase feelings of fullness, and support significant weight loss by decreasing calorie intake

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It works through two hormone pathways, GIP and GLP-1

Decision comparison matrix For users who are comparing these peptides to newer options in the class, the retatrutide vs tirzepatide and retatrutide vs semaglutide comparisons provide additional context about where the next generation of incretin therapies is heading

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Lean proteins should form the foundation of meals, as adequate protein intake helps preserve lean muscle mass during weight loss and promotes satiety