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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia

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doi: 10.1152/ajpregu.00520.2015 [DOI] [PMC free article] [PubMed] [Google Scholar] 29

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Serious digestive issues like severe stomach pain, pancreatitis, or gallbladder problems have been reported
There aren't enough studies to determine its effects on pets, so veterinarians advise against its use until its safety is established