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In preclinical studies, high alcoholconsuming animals are reported to decrease their alcohol intake more than low alcoholconsuming animals when treated with GLP1RAs [52, 55]

Use caution and monitor renal function when initiating or increasing doses of semaglutide in patients with renal impairment or any patients who report severe gastrointestinal reactions during use

While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function

Vitamin D 2,000-4,000 IU daily

We plan for keeping it off from day one whether that means gradually tapering, staying at a maintenance dose, or transitioning off with new habits locked in

doi: 10.1056/nejm199909163411204