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doi: 10.1007/s11095-022-03302-1

Furthermore, the activation of GLP-1R signaling in the ventromedial hypothalamus (VMH) can also control energy expenditure by promoting food intake-independent weight loss by inducing brown adipose tissue (BAT) thermogenesis and browning through a sympathetic drive to BAT [6]

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They might also extend the dosing interval to one dose every two weeks instead of one
