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Insurers typically require documentation of inadequate glycemic control despite metformin therapy, contraindications to other agents, or presence of specific comorbidities that make GLP-1 therapy medically necessary

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RiskBenefit Assessment and Pharmacovigilance Needs Given the widespread use of GLP-1RAs and other incretin-based agents for obesity and T2D, comprehensive evaluation of even common GI adverse effects remains limited

References Eshak N, Irani A, Sullivan M